Prof. Dr. Dr. P.Simon  |  Dr. E. Lachtermann



Strepp, T., Blumkaitis, J. C., Haller, N., und Stöggl, T. L. (2024). Adding LIT to HIIT – Is Low-Intensity Training Vital for Endurance-Trained Athletes during a 7-day HIIT Shock Microcycles?. Medicine & Science in Sports & Exercise. Published online. DOI
Blumkaitis, J. C., Nunes, N., Strepp, T., et al. (2024). Exploring sex differences in blood-based biomarkers following exhaustive exercise using bioinformatics analysis. Biology of Sport. Published online. DOI



Haller, N. (2023). The potential of wearables to increase physical activity among children and adolescents. Forum Kinder- und Jugendsport, 4(2), 124-127. DOI
Brahmer, A., Geiss, C., Lygeraki, A., et al. (2023). Assessment of technical and clinical utility of a bead-based flow cytometry platform for multiparametric phenotyping of CNS-derived extracellular vesicles. CELL COMMUNICATION AND SIGNALING, 21(1). DOI Author/Publisher URL
De Falco, A., Olinger, C. M., Klink, B., et al. (2023). Digital PCR cluster predictor: a universal R-package and shiny app for the automated analysis of multiplex digital PCR data. BIOINFORMATICS, 39(5). DOI Author/Publisher URL
Dettweiler, U., Gerchen, M., Mall, C., et al. (2023). Choice matters: Pupils’ stress regulation, brain development and brain function in an outdoor education project. BRITISH JOURNAL OF EDUCATIONAL PSYCHOLOGY, 93, 152-173. DOI Author/Publisher URL
Haller, N., Behringer, M., Reichel, T., et al. (2023). Blood-Based Biomarkers for Managing Workload in Athletes: Considerations and Recommendations for Evidence-Based Use of Established Biomarkers. SPORTS MEDICINE, 53(7), 1315-1333. DOI Author/Publisher URL
Haller, N., Kranzinger, S., Kranzinger, C., et al. (2023). Predicting Injury and Illness with Machine Learning in Elite Youth Soccer: A Comprehensive Monitoring Approach over 3 Months. JOURNAL OF SPORTS SCIENCE AND MEDICINE. Published. DOI Author/Publisher URL
Haller, N., Kranzinger, S., Kranzinger, C., et al. (2023). Predicting Injury and Illness with Machine Learning in Elite Youth Soccer: A Comprehensive Monitoring Approach over 3 Months. JOURNAL OF SPORTS SCIENCE AND MEDICINE, 22(3), 476-487. DOI Author/Publisher URL
Haller, N., Reichel, T., Zimmer, P., et al. (2023). Blood-Based Biomarkers for Managing Workload in Athletes: Perspectives for Research on Emerging Biomarkers. SPORTS MEDICINE, 53(11), 2039-2053. DOI Author/Publisher URL
Herhaus, B., Neuberger, E., Juskeviciute, E., et al. (2023). Kinetics of Plasma Cell-Free DNA under a Highly Standardized and Controlled Stress Induction. CELLS, 12(4). DOI Author/Publisher URL
Hillen, B., Lopez, D. A., Marzano-Felisatti, J. M., et al. (2023). Acute physiological responses to a pyramidal exercise protocol and the associations with skin temperature variation in different body areas. JOURNAL OF THERMAL BIOLOGY, 115. DOI Author/Publisher URL
Hillen, B., Lopez, D. A., Pfirrmann, D., et al. (2023). An exploratory, intra- and interindividual comparison of the deep neural network automatically measured calf surface radiation temperature during cardiopulmonary running and cycling exercise testing: A preliminary study. JOURNAL OF THERMAL BIOLOGY, 113. DOI Author/Publisher URL
Hoeter, K., Neuberger, E., Fischer, S., et al. (2023). Evidence for the utility of cfDNA plasma concentrations to predict disease severity in COVID-19: a retrospective pilot study. PEERJ, 11. DOI Author/Publisher URL
Hoff, T. A., Heller, S., Reichel, J. L., et al. (2023). Cigarette Smoking, Risky Alcohol Consumption, and Marijuana Smoking among University Students in Germany: Identification of Potential Sociodemographic and Study-Related Risk Groups and Predictors of Consumption. HEALTHCARE, 11(24). DOI Author/Publisher URL
Juskeviciute, E., Neuberger, E., Eimantas, N., et al. (2023). Three-week sprint interval training (SIT) reduces cell-free DNA and low-frequency fatigue but does not induce VO2max improvement in older men. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY. Published. DOI Author/Publisher URL
Knoll, R. L., Jarquin-Diaz, V. H., Klopp, J., et al. (2023). Resilience and stability of the CF- intestinal and respiratory microbiome during nutritional and exercise intervention. BMC MICROBIOLOGY, 23(1). DOI Author/Publisher URL
Kuehn, M., Wypyrsczyk, L., Stoessel, S., et al. (2023). Physical Activity as a Treatment for Cancer-Related Fatigue in Children, Adolescents and Young Adults: A Systematic Review. CHILDREN-BASEL, 10(3). DOI Author/Publisher URL
Ludwig, K., Malatantis-Ewert, S., Huppertz, T., et al. (2023). Central Apneic Event Prevalence in REM and NREM Sleep in OSA Patients: A Retrospective, Exploratory Study. BIOLOGY-BASEL, 12(2). DOI Author/Publisher URL
Seifen, C., Pordzik, J., Bahr, K., et al. (2023). Accumulating Comorbidities May Promote Increasing Severity of Obstructive Sleep Apnea with Aging in Males but Not in Females. JOURNAL OF PERSONALIZED MEDICINE, 13(1). DOI Author/Publisher URL
Seifen, C., Pordzik, J., Huppertz, T., et al. (2023). Serum Ferritin Levels in Severe Obstructive Sleep Apnea. DIAGNOSTICS, 13(6). DOI Author/Publisher URL
Stoggl, T. L., Strepp, T., Blumkaitis, J., et al. (2023). Unraveling the mystery of isocaloric endurance training - Influence of exercise modality, biological sex, and physical fitness. METABOLISM-CLINICAL AND EXPERIMENTAL, 144. DOI Author/Publisher URL
Ulrich, R., Cleret, L., Comstock, R. D., et al. (2023). Assessing the Prevalence of Doping Among Elite Athletes: An Analysis of Results Generated by the Single Sample Count Method Versus the Unrelated Question Method. SPORTS MEDICINE-OPEN, 9(1). DOI Author/Publisher URL
Wuttke, A., Steinmetz, A., Endres, K., et al. (2023). Behavioral Activation by Wearable Devices in Patients with Late-Life Depression A Randomized Crossover Study. GEROPSYCH-THE JOURNAL OF GERONTOPSYCHOLOGY AND GERIATRIC PSYCHIATRY. Published. DOI Author/Publisher URL



    Paoli, L., Hoppeler, H., Mahler, H., Simon, P., Sörgel, F., & Treutlein, G. (2022). Doping für Deutschland: Die »Evaluierungskommission Freiburger Sportmedizin«: Geschichte, Ergebnisse und sportpolitische Forderungen (1. Aufl.). LINK


    Hillen, B., López, D. A., Schömer, E., Nägele, M., & Simon, P. (2022). Towards Exercise Radiomics: Deep Neural Network-Based Automatic Analysis of Thermal Images Captured During Exercise. IEEE Journal of Biomedical and Health Informatics , 1–11. DOI

    Neuberger, E. W. I., & Simon, P. (2022). Cell-free DNA in sports medicine: Implications for clinical laboratory medicine. LaboratoriumsMedizin. DOI

    Dehnen, D., Neuberger, E., In der Schmitten, J., Giagkou, E., Simon, P., & Botzenhardt, S. (2022). cfDNA as a surrogate marker for COVID-19 severity in patients with influenza-like symptoms with and without SARS-CoV-2 infections in general practice: A study protocol for a prospective cohort study. BMJ Open, 12 (6), e058647. DOI

    Haller, N., Tomaskovic, A., Stöggl, T., Simon, P., & Neuberger, E. (2022). Feasibility of Cell-Free DNA Measurement from the Earlobe during Physiological Exercise Testing. Diagnostics, 12 (6), 1379. DOI

    Bahr, K., Simon, P., Leggewie, B., Gouveris, H., & Schattenberg, J. (2022). The Snoring Index Identifies Risk of Non-Alcoholic Fatty Liver Disease in Patients with Obstructive Sleep Apnea Syndrome. Biology, 11(1), 10. DOI

    Dietz, P., Werner, A., Reichel, J., Schäfer, M., Mülder, L., Beutel, M., Simon, P., Letzel, S., & Heller, S. (2022). The Prevalence of Pharmacological Neuroenhancement Among University Students Before and During the COVID-19-Pandemic: Results of Three Consecutive Cross-Sectional Survey Studies in Germany. Frontiers in Public Health, 10, 813328. DOI

    Haller, N. (2022). Web-based exercise therapy for the treatment of depression. Sports Psychiatry. DOI

    Haller, N., Hübler, E., Stöggl, T., & Simon, P. (2022). Evidence‐Based Recovery in Soccer – Low‐Effort Approaches for Practitioners. Journal of Human Kinetics, 82, 75–99. DOI

    Heller, S., Tibubos, A. N., Hoff, T., Werner, A., Reichel, J., Mülder, L., Schäfer, M., Pfirrmann, D., Stark, B., Rigotti, T., Simon, P., Beutel, M., Letzel, S., & Dietz, P. (2022). Potential risk groups and psychological, psychosocial, and health behavioral predictors of pharmacological neuroenhancement among university students in Germany. Scientific Reports, 12. DOI

    Neuberger, E. W. I., Sontag, S., Brahmer, A., Philippi, K. F. A., Radsak, M. P., Wagner, W., & Simon, P. (2022). Physical activity specifically evokes release of cell-free DNA from granulocytes thereby affecting liquid biopsy. Clinical Epigenetics, 14, 29. DOI

    Stöggl, T., Blumkaitis, J., Strepp, T., Sareban, M., Simon, P., Neuberger, E., Finkenzeller, T., Nunes, N., Aglas, L., & Haller, N. (2022). The Salzburg 10/7 HIIT shock cycle study: The effects of a 7-day high-intensity interval training shock microcycle with or without additional low-intensity training on endurance performance, well-being, stress and recovery in endurance trained athletes—study protocol of a randomized controlled trial. BMC Sports Science, Medicine and Rehabilitation, 14. DOI




    Dietz, P., Quermann, A., van Poppel, M. N. M., Striegel, H., Schröter, H., Ulrich, R., & Simon, P. (2021). Correction: Physical and cognitive doping in university students using the unrelated question model (UQM): Assessing the influence of the probability of receiving the sensitive question on prevalence estimation. PloS One, 16(10), e0258705. DOI

    Fleckenstein, J., Neuberger, E. W. I., Bormuth, P., Comes, F., Schneider, A., Banzer, W., Fischer, L., & Simon, P. (2021). Investigation of the Sympathetic Regulation in Delayed Onset Muscle Soreness: Results of an RCT. Frontiers in Physiology, 12, 697335. DOI

    Hasanzadeh, A., Alamdaran, M., Ahmadi, S., Nourizadeh, H., Bagherzadeh, M. A., Mofazzal Jahromi, M. A., Simon, P., Karimi, M., & Hamblin, M. R. (2021). Nanotechnology against COVID-19: Immunization, diagnostic and therapeutic studies. Journal of Controlled Release, 336, 354–374. DOI

    Hillen, B., Simon, P., Schlotter, S., Nitsche, O., Bähner, V., Poplawska, K., & Pfirrmann, D. (2021). Feasibility and implementation of a personalized, web-based exercise intervention for people with cystic fibrosis for 1 year. BMC Sports Science, Medicine and Rehabilitation, 13(1), 95. DOI

    Hoeter, K., Neuberger, E., Fischer, S., Herbst, M., Juškevičiūtė, E., Rossmann, H., Sprinzl, M. F., Simon, P., Bodenstein, M., & Schäfer, M. K. E. (2021). Evidence for the utility of cfDNA plasma concentrations to predict disease severity in COVID-19 (S. 2021.04.29.21256291). medRxiv. DOI

    Neuberger, E. W. I., Brahmer, A., Ehlert, T., Kluge, K., Philippi, K. F. A., Boedecker, S. C., Weinmann-Menke, J., & Simon, P. (2021). Validating quantitative PCR assays for cfDNA detection without DNA extraction in exercising SLE patients. Scientific Reports, 11(1), 13581. DOI

    Neuberger, E. W. I., Hillen, B., Mayr, K., Simon, P., Krämer-Albers, E.-M., & Brahmer, A. (2021). Kinetics and Topology of DNA Associated with Circulating Extracellular Vesicles Released during Exercise. Genes, 12(4), 522. DOI

    Ochmann, D. T., Philippi, K. F. A., Zeier, P., Sandner, M., Hillen, B., Neuberger, E. W. I., Ruiz de Azua, I., Lieb, K., Wessa, M., Lutz, B., Simon, P., & Brahmer, A. (2021). Association of Innate and Acquired Aerobic Capacity With Resilience in Healthy Adults: Protocol for a Randomized Controlled Trial of an 8-Week Web-Based Physical Exercise Intervention. JMIR Research Protocols, 10(11), e29712. DOI

    Reichel, J. L., Rigotti, T., Tibubos, A. N., Werner, A. M., Schäfer, M., Edelmann, D., Pfirrmann, D., Deci, N., Beutel, M. E., Stark, B., Simon, P., Letzel, S., & Dietz, P. (2021). Challenge Accepted! A Critical Reflection on How to Perform a Health Survey Among University Students—An Example of the Healthy Campus Mainz Project. Frontiers in Public Health, 9. DOI





  • Bahr, K., Bopp, M., Kewader, W., Dootz, H., Döge, J., Huppertz, T., Simon, P., Prokosch-Willing, V., Matthias, C., & Gouveris, H. (2020). Obstructive sleep apnea as a risk factor for primary open angle glaucoma and ocular hypertension in a monocentric pilot study. Respiratory Research, 21(1), 258. DOI
  • Boedecker, S. C., Philippi, K. F. A., Neuberger, E., Schmidt, S., Pfirrmann, D., Haller, N., Schwarting, A., Simon, P., & Weinmann-Menke, J. (2020). Twelve-Week Internet-Based Individualized Exercise Program in Adults With Systemic Lupus Erythematosus: Protocol for a Randomized Controlled Trial. JMIR Research Protocols, 9(11), e18291. DOI
  • Brahmer, A., & Krämer-Albers, E.-M. (2020). “Brainstorming”: Extracellular Vesicles in Physical Activity and Neuronal Health. Trillium Exctracellular Vesicles, 2, 54–59. DOI
  • Brahmer, A., Neuberger, E. W. I., Simon, P., & Krämer-Albers, E.-M. (2020). Considerations for the Analysis of Small Extracellular Vesicles in Physical Exercise. Frontiers in Physiology, 11. DOI
  • Dietz, P., Reichel, J. L., Edelmann, D., Werner, A. M., Tibubos, A. N., Schäfer, M., Simon, P., Letzel, S., & Pfirrmann, D. (2020). A Systematic Umbrella Review on the Epidemiology of Modifiable Health Influencing Factors and on Health Promoting Interventions Among University Students. Frontiers in Public Health, 8, 137.  DOI
  • Heller, S., Ulrich, R., Simon, P., & Dietz, P. (2020). Refined Analysis of a Cross-Sectional Doping Survey Among Recreational Triathletes: Support for the Nutritional Supplement Gateway Hypothesis. Frontiers in Psychology, 11, 561013. DOI
  • Hillen, B., Pfirrmann, D., Nägele, M., & Simon, P. (2020). Infrared Thermography in Exercise Physiology: The Dawning of Exercise Radiomics. Sports Medicine (Auckland, N.Z.), 50(2), 263–282. DOI
  • Hoffmann, S. W., Dreher, M., Urschitz, M. S., & Simon, P. (2020). Beyond BMI: Waist circumference and social environment is associated with motor performance ability in kindergartners. BMC Pediatrics, 20(1), 4. DOI
  • Simon, P. (2020). Robust Estimation of Infection Fatality Rates during the Early Phase of a Pandemic (S. 2020.04.08.20057729). medRxiv. DOI
  • Tahir, E., Scherz, B., Starekova, J., Muellerleile, K., Fischer, R., Schoennagel, B., Warncke, M., Stehning, C., Cavus, E., Bohnen, S., Radunski, U. K., Blankenberg, S., Simon, P., Pressler, A., Adam, G., Patten, M., & Lund, G. K. (2020). Acute impact of an endurance race on cardiac function and biomarkers of myocardial injury in triathletes with and without myocardial fibrosis. European Journal of Preventive Cardiology, 27(1), 94–104. DOI
  • Wackerhage, H., Everett, R., Krüger, K., Murgia, M., Simon, P., Gehlert, S., Neuberger, E., Baumert, P., & Schönfelder, M. (2020). Sport, exercise and COVID-19, the disease caused by the SARS-CoV-2 coronavirus. Deutsche Zeitschrift für Sportmedizin, 5. DOI




  • Becker, C., Schmidt, S., Neuberger, E. W. I., Kirsch, P., Simon, P., & Dettweiler, U. (2019). Children’s Cortisol and Cell-Free DNA Trajectories in Relation to Sedentary Behavior and Physical Activity in School: A Pilot Study. Frontiers in Public Health, 7. LINK
  • Brahmer, A., Neuberger, E., Esch-Heisser, L., Haller, N., Jorgensen, M. M., Baek, R., Möbius, W., Simon, P., & Krämer-Albers, E.-M. (2019). Platelets, endothelial cells and leukocytes contribute to the exercise-triggered release of extracellular vesicles into the circulation. Journal of Extracellular Vesicles, 8(1), 1615820. DOI
  • Dreher, M., Hoffmann, S. W., Brendel, C., Heser, D., & Simon, P. (2019). Convenience Behavior and Being Overweight in Adults: Development and Validation of the Convenience Behavior Questionnaire. Frontiers in Public Health, 7, 20. DOI
  • Ehlert, T., Botzenhardt, S., & Simon, P. (2019). Changes of Total and Tumor Specific Cell Free Dna During an Exhaustive Cycling Exercise Test. Medicine & Science in Sports & Exercise. DOI
  • Gehrke, N., Biedenbach, J., Huber, Y., Straub, B. K., Galle, P. R., Simon, P., & Schattenberg, J. M. (2019). Voluntary exercise in mice fed an obesogenic diet alters the hepatic immune phenotype and improves metabolic parameters – an animal model of life style intervention in NAFLD. Scientific Reports, 9(1), 4007. DOI
  • Gehrke, N., Biedenbach, J., Huber, Y., Straub, B., Galle, P., Simon, P., & Schattenberg, J. (2019). Voluntary distance running prevents disease progression in mice with non-alcoholic fatty liver disease (NAFLD). 57DOI
  • Haller, N., Ehlert, T., Schmidt, S., & Simon, P. (2019). Circulating DNA As A Monitoring Tool In Professional Soccer: 2110 Board #266 May 30 3:30 PM - 5:00 PM. Medicine & Science in Sports & Exercise, 51(6S), 575. DOI
  • Haller, N., Ehlert, T., Schmidt, S., Ochmann, D., Sterzing, B., Grus, F., & Simon, P. (2019). Circulating, Cell-Free DNA for Monitoring Player Load in Professional Football. International Journal of Sports Physiology and Performance, 14(6), 718–726. DOI
  • Hillen, B., & Simon, P. (2019). The Temperature Surface Radiation Pattern - A non-invasive Insight into Skin Blood Flow Response to Exercise: 1857 Board #13 May 30 2:00 PM - 3:30 PM. Medicine & Science in Sports & Exercise, 51(6S), 491–492. DOI
  • Hillen, B., Simon, P., Grimminger, P. P., Gockel, I., & Pfirrmann, D. (2019). Use of a Perioperative Web-Based Exercise Program for a Patient with Barrett’s Carcinoma Scheduled for Esophagectomy. Case Reports in Oncology, 12(3), 755–764. DOI
  • Huber, Y., Pfirrmann, D., Gebhardt, I., Labenz, C., Clément, K., Karsdal, M. A., Galle, P. R., Simon, P., & Schattenberg, J. M. (2019). Ein individualisiertes 8-wöchiges Sportprogramm verbessert bei Patienten mit NAFLD die hepatische Fibrose und Inflammation und steigert die Vielfalt des Mikrobioms. Zeitschrift für Gastroenterologie, 57(9), KV 247. DOI
  • Huber, Y., Pfirrmann, D., Gebhardt, I., Labenz, C., Gehrke, N., Straub, B. K., Ruckes, C., Bantel, H., Belda, E., Clément, K., Leeming, D. J., Karsdal, M. A., Galle, P. R., Simon, P., & Schattenberg, J. M. (2019). Improvement of non-invasive markers of NAFLD from an individualised, web-based exercise program. Alimentary Pharmacology & Therapeutics, 50(8), 930–939. DOI
  • Huber, Y., Pfirrmann, D., Labenz, C., Kalliga, E., Gehrke, N., Straub, B., Leeming, D., Bantel, H., Galle, P., Simon, P., & Schattenberg, J. (2019). SAT-349-Improvement of hepatic inflammation and fibrosis independently of weight loss from a short, individualized, web-based exercise program in patients with NAFLD. Journal of Hepatology, 70, e791. DOI
  • Lund, G. K., Muellerleile, K., Pressler, A., Simon, P., & Tahir, E. (2019). Reply to the letter to the editor. European Journal of Preventive Cardiology, 26(16), 1783–1784. DOI
  • Neuberger, E., Brahmer, A., Boztepe, B., Krämer-Albers, E.-M., & Simon, P. (2019). Association Of Circulating Cell-free Dna Released During Physical Exercise With Extracellular Vesicles: 2115 Board #271 May 30 3:30 PM - 5:00 PM. Medicine & Science in Sports & Exercise, 51, 576. DOI
  • Ochmann, D., Kreuz, C., Wenzel, S., & Simon, P. (2019). cfDNA As A Metabolic Marker: 1400 Board #162 May 30 10:30 AM - 12:00 PM. Medicine & Science in Sports & Exercise, 51(6S), 377–378. DOI
  • Pfirrmann, D., Huber, Y., Schattenberg, J. M., & Simon, P. (2019). Web-Based Exercise as an Effective Complementary Treatment for Patients With Nonalcoholic Fatty Liver Disease: Intervention Study. Journal of Medical Internet Research, 21(1), e11250. DOI
  • Pitsiladis, Y. P., Abatzis-Papadopoulos, M., Ali, N., Aggeloudis, S., Atkinson, C., Constandache, B., Ganus, Y., Geladas, N., Giakoumakis, S. I., Güner, R., Howman, D., Lima, G. H. O., Khristenko, E., Koskolou, M., Klissouras, V., Ladikas, M., Loland, S., McNamee, M. J., Pardos, B. M., … Yang, H. (2019). The Olympia Declaration. Current Sports Medicine Reports, 18(12), 448–451. DOI
  • Simon, P., Brahmer, A., Haller, N., Esch-Heisser, L., Neuberger, E. W., & Krämer-Albers, E.-M. (2019). Origin of Extracellular Vesicles Released During Exercise: 2391 Board #55 May 31 9:30 AM - 11:00 AM. Medicine & Science in Sports & Exercise, 51(6S), 654. DOI
  • Simon, P., & Dettweiler, U. (2019). Current Anti-Doping Crisis: The Limits of Medical Evidence Employing Inductive Statistical Inference. Sports Medicine, 49(4), 497–500. DOI
  • Sterzing, B., Ehlert, T., Breitbach, S., & Simon, P. (2019). Differences In Performance Traits In Intermittent Versus Continuous Exercise Testing Of Handball Players and Triathletes: 3438 Board #126 June 1 8:00 AM - 9:30 AM. Medicine & Science in Sports & Exercise, 51, 944. DOI
  • Tahir, E., Starekova, J., Muellerleile, K., Freiwald, E., von Stritzky, A., Münch, J., Avanesov, M., Weinrich, J. M., Stehning, C., Cavus, E., Bohnen, S., Radunski, U. K., Blankenberg, S., Adam, G., Simon, P., Pressler, A., Patten, M., & Lund, G. K. (2019). Impact of Myocardial Fibrosis on Left Ventricular Function Evaluated by Feature-Tracking Myocardial Strain Cardiac Magnetic Resonance in Competitive Male Triathletes With Normal Ejection Fraction. Circulation Journal: Official Journal of the Japanese Circulation Society, 83(7), 1553–1562. DOI




  • Brahmer, A., Simon, P., & Krämer-Albers, E.-M. (2018). Origin of extracellular vesicles released during exhaustive exercise. Journal of Extracellular Vesicles, 7, 29. LINK
  • Dietz, P., Quermann, A., van Poppel, M. N. M., Striegel, H., Schröter, H., Ulrich, R., & Simon, P. (2018). Physical and cognitive doping in university students using the unrelated question model (UQM): Assessing the influence of the probability of receiving the sensitive question on prevalence estimation. PloS One, 13(5), e0197270. DOI
  • Dreher, M., Ehlert, T., Simon, P., & Neuberger, E. W. I. (2018). Boost Me: Prevalence and Reasons for the Use of Stimulant Containing Pre Workout Supplements Among Fitness Studio Visitors in Mainz (Germany). Frontiers in Psychology, 9. LINK
  • Gouveris, H., Bahr, K., Jahn, C., Matthias, C., & Simon, P. (2018). The Apnea-Hypopnea Index Underestimates Systemic Inflammation in Women with Sleep-Disordered Breathing. Journal of Women’s Health (2002), 27(7), 920–926. DOI
  • Haller, N., Helmig, S., Taenny, P., Petry, J., Schmidt, S., & Simon, P. (2018). Circulating, cell-free DNA as a marker for exercise load in intermittent sports. PLoS ONE, 13(1), e0191915. DOI
  • Haller, N., Lorenz, S., Pfirrmann, D., Koch, C., Lieb, K., Dettweiler, U., Simon, P., & Jung, P. (2018). Individualized Web-Based Exercise for the Treatment of Depression: Randomized Controlled Trial. JMIR Mental Health, 5(4), e10698. DOI
  • Pfirrmann, D., Haller, N., Huber, Y., Jung, P., Lieb, K., Gockel, I., Poplawska, K., Schattenberg, J. M., & Simon, P. (2018). Applicability of a Web-Based, Individualized Exercise Intervention in Patients With Liver Disease, Cystic Fibrosis, Esophageal Cancer, and Psychiatric Disorders: Process Evaluation of 4 Ongoing Clinical Trials. JMIR Research Protocols, 7(5), e106. DOI
  • Pfirrmann D, Huber Y, Schattenberg JM, Simon P. Lifestyle Change in Patients with non-alcoholic Fatty Liver Sisease (NAFLD) through an Internet-assisted Sports Intervention - The HELP Study
    INTERNIST. 2018 Apr, Volume: 59 Pages: S21-S21
  • Pfirrmann, D., Simon, P., Mehdorn, M., Hänsig, M., Stehr, S., Selig, L., Weimann, A., Knödler, M., Lordick, F., Mehnert-Theuerkauf, A., & Gockel, I. (2019). Präkonditionierung vor viszeralonkologischen Operationen: Ein Paradigmenwechsel in der Viszeralchirurgie? best practice onkologie, 14. DOI
  • Piegeler, T., Stehr, S. N., Pfirrmann, D., Knödler, M., Lordick, F., Mehnert, A., Selig, L., Weimann, A., Mehdorn, M., Gockel, I., & Simon, P. (2018). Spezialsituationen der Präkonditionierung und Prähabilitation in der onkologischen Viszeralchirurgie. Der Chirurg, 89(11), 903–908. DOI
  • Simon, P., Neuberger, E. W., Wang, G., & Pitsiladis, Y. P. (2018). Antidoping Science: Important Lessons From the Medical Sciences. Current Sports Medicine Reports, 17(10), 326–331. DOI




  • Haller, N., & Simon, P. (2017). Sport und Bewegung zur Therapie und Prävention (S. 187–196). DOI


  • Dettweiler, U., Becker, C., Auestad, B. H., Simon, P., & Kirsch, P. (2017). Stress in School. Some Empirical Hints on the Circadian Cortisol Rhythm of Children in Outdoor and Indoor Classes. International Journal of Environmental Research and Public Health, 14(5), E475. DOI
  • Dettweiler, U., Lauterbach, G., Becker, C., & Simon, P. (2017). A Bayesian Mixed-Methods Analysis of Basic Psychological Needs Satisfaction through Outdoor Learning and Its Influence on Motivational Behavior in Science Class. Frontiers in Psychology, 8, 2235. DOI
  • Ehlert, T., Tug, S., Brahmer, A., Neef, V., Heid, F., Werner, C., Jansen-Winkeln, B., Kneist, W., Lang, H., Gockel, I., & Simon, P. (2017). Establishing PNB-qPCR for quantifying minimal ctDNA concentrations during tumour resection. Scientific Reports, 7(1), 8876. DOI
  • Endler, S., Weichert, S., Sterzing, B., Simon, P., & Pfeiffer, M. (2017). The PerPot Simulated Anaerobic Threshold—A Comparison to Typical Lactate-based Thresholds. International Journal of Human Movement and Sports Sciences, 5, 9–15. DOI
  • Fleckenstein, J., Simon, P., König, M., Vogt, L., & Banzer, W. (2017). The pain threshold of high-threshold mechanosensitive receptors subsequent to maximal eccentric exercise is a potential marker in the prediction of DOMS associated impairment. PloS One, 12(10), e0185463. DOI
  • Franke, A. G., Dietz, P., Ranft, K., Balló, H., Simon, P., & Lieb, K. (2017). The Use of Pharmacologic Cognitive Enhancers in Competitive Chess. Epidemiology, 28(6), e57. DOI
  • Gockel, I., Pfirrmann, D., Jansen-Winkeln, B., & Simon, P. (2017). The dawning of perioperative care in esophageal cancer. Journal of Thoracic Disease, 9(10), 3488–3492. DOI
  • Huber, Y., Pfirrmann, D., Gebhardt, I., Labenz, C., Simon, P., Wörns, M., Galle, P., & Schattenberg, J. (2017). Individualisierte Sportintervention bei Patienten mit nicht-alkoholischer Fettlebererkrankung (HELP-Studie). Zeitschrift für Gastroenterologie, 55(8), FV 12. DOI
  • Huber, Y., Gehrke, N., Biedenbach, J., Helmig, S., Simon, P., Straub, B. K., Bergheim, I., Huber, T., Schuppan, D., Galle, P. R., Wörns, M. A., Schuchmann, M., & Schattenberg, J. M. (2017). Voluntary distance running prevents TNF-mediated liver injury in mice through alterations of the intrahepatic immune milieu. Cell Death & Disease, 8(6), e2893. DOI
  • Mall, C., Kirsch, P., Simon, P., Mess, F., & Dettweiler, U. (2017, September 14). Die Bewegungsaktivität von Schülerinnen und Schülern im Draußenunterricht. LINK
  • Neuberger, E. W. I., & Simon, P. (2017). Gene and Cell Doping: The New Frontier - Beyond Myth or Reality. Medicine and Sport Science, 62, 91–106. DOI
  • Pfirrmann, D., Tug, S., Brosteanu, O., Mehdorn, M., Busse, M., Grimminger, P. P., Lordick, F., Glatz, T., Hoeppner, J., Lang, H., Simon, P., & Gockel, I. (2017). Internet-based perioperative exercise program in patients with Barrett’s carcinoma scheduled for esophagectomy [iPEP - study] a prospective randomized-controlled trial. BMC Cancer, 17(1), 413. DOI
  • Tug, S., Mehdorn, M., Helmig, S., Breitbach, S., Ehlert, T., & Simon, P. (2017). Exploring the Potential of Cell-Free-DNA Measurements After an Exhaustive Cycle-Ergometer Test as a Marker for Performance-Related Parameters. International Journal of Sports Physiology and Performance, 12(5), 597–604. DOI
  • Tug, S., Tross, A.-K., Hegen, P., Neuberger, E. W. I., Helmig, S., Schöllhorn, W., & Simon, P. (2017). Acute effects of strength exercises and effects of regular strength training on cell free DNA concentrations in blood plasma. PLOS ONE, 12(9), e0184668. DOI
  • Ulrich, R., Pope, H. G., Cléret, L., Petróczi, A., Nepusz, T., Schaffer, J., Kanayama, G., Comstock, R. D., & Simon, P. (2018). Doping in Two Elite Athletics Competitions Assessed by Randomized-Response Surveys. Sports Medicine (Auckland, N.Z.), 48(1), 211–219. DOI



  • Neuberger, E., & Simon, P. (2016). Genetische Tests im Sport: Können wir schon empirische Evidenz von empirischem Nonsens unterscheiden? In Gendoping: Herausforderung für Sport und Gesellschaft (1. Aufl., S. 193–215). Springer Spektrum. LINK


  • Simon P. „Ein Stich ins Herz des Sports” - Men`sHealth, Nov.2016 (PDF)


  • Dietz, P., Dalaker, R., Letzel, S., Ulrich, R., & Simon, P. (2016). Analgesics use in competitive triathletes: Its relationship to doping and on predicting its usage. Journal of Sports Sciences, 34(20), 1965–1969. DOI
  • Haller, N., Tug, S., Breitbach, S., Jörgensen, A., & Simon, P. (2017). Increases in Circulating Cell-Free DNA During Aerobic Running Depend on Intensity and Duration. International Journal of Sports Physiology and Performance, 12(4), 455–462. DOI
  • Könecke, T., Primke, D., & Simon, P. (2016). Dropout und Therapietreue von Herzpatienten in Rehabilitationssportgruppen – eine Übersicht über einschlägige Studien. Deutsche Zeitschrift für Sportmedizin, 2016, 244–248. DOI
  • Neuberger, E. W. I., Perez, I., Le Guiner, C., Moser, D., Ehlert, T., Allais, M., Moullier, P., Simon, P., & Snyder, R. O. (2016). Establishment of two quantitative nested qPCR assays targeting the human EPO transgene. Gene Therapy, 23(4), 330–339. DOI
  • Pfirrmann, D., Herbst, M., Ingelfinger, P., Simon, P., & Tug, S. (2016). Analysis of Injury Incidences in Male Professional Adult and Elite Youth Soccer Players: A Systematic Review. Journal of Athletic Training, 51(5), 410–424. DOI
  • Schröter, H., Studzinski, B., Dietz, P., Ulrich, R., Striegel, H., & Simon, P. (2016). A Comparison of the Cheater Detection and the Unrelated Question Models: A Randomized Response Survey on Physical and Cognitive Doping in Recreational Triathletes. PLOS ONE, 11(5), e0155765. DOI
  • Zahn, D., Tug, S., Wenzel, M., Simon, P., & Kubiak, T. (2016). Glucose metabolism and self-regulation—Is insulin resistance a valid proxy of self-control? Personality and Individual Differences, 99, 38–45. DOI





  • Dettweiler, U., Ünlü, A., Lauterbach, G., Legl, A., Simon, P., & Kugelmann, C. (2015). Alien at home: Adjustment strategies of students returning from a six-months over-sea’s educational programme. International Journal of Intercultural Relations, 44, 72–87. DOI
  • Frühbeis, C., Helmig, S., Tug, S., Simon, P., & Krämer-Albers, E.-M. (2015). Physical exercise induces rapid release of small extracellular vesicles into the circulation. Journal of Extracellular Vesicles, 4, 28239. DOI
  • Helmig, S., Frühbeis, C., Krämer-Albers, E.-M., Simon, P., & Tug, S. (2015). Release of bulk cell free DNA during physical exercise occurs independent of extracellular vesicles. European Journal of Applied Physiology, 115(11), 2271–2280. DOI
  • Neuberger, E., Mooses, M., Durussel, J., Wang, J., Lees, M., Mooses, K., Brahmer, A., Wang, G., Pitsiladis, Y., & Simon, P. (2015). Small RNA sequencing of red blood cell specific miRNAs reveals expression changes after 6 weeks of recombinant EPO (rEPO) administration in healthy recreational athletes. American Journal of Hematology, 90, E171–E171.
  • Tug, S., Helmig, S., Deichmann, E. R., Schmeier-Jürchott, A., Wagner, E., Zimmermann, T., Radsak, M., Giacca, M., & Simon, P. (2015). Exercise-induced increases in cell free DNA in human plasma originate predominantly from cells of the haematopoietic lineage. Exercise Immunology Review, 21, 164–173. LINK



  • Breitbach, S., Tug, S., Helmig, S., Zahn, D., Kubiak, T., Michal, M., Gori, T., Ehlert, T., Beiter, T., & Simon, P. (2014). Direct Quantification of Cell-Free, Circulating DNA from Unpurified Plasma. PLOS ONE, 9(3), e87838. DOI
  • Breitbach, S., Tug, S., & Simon, P. (2014). Conventional and genetic talent identification in sports: Will recent developments trace talent? Sports Medicine (Auckland, N.Z.), 44(11), 1489–1503. DOI
  • Breitbach, S., Sterzing, B., Magallanes, C., Tug, S., & Simon, P. (2014). Direct measurement of cell-free DNA from serially collected capillary plasma during incremental exercise. Journal of Applied Physiology (Bethesda, Md.: 1985), 117(2), 119–130. DOI
  • Dietz, P., Ulrich, R., Niess, A., Best, R., Simon, P., & Striegel, H. (2014). Prediction profiles for nutritional supplement use among young German elite athletes. International Journal of Sport Nutrition and Exercise Metabolism, 24(6), 623–631. DOI
  • Hoffmann, S. W., Tug, S., & Simon, P. (2014). Child-caregivers’ body weight and habitual physical activity status is associated with overweight in kindergartners. BMC Public Health, 14(1), 822. DOI
  • Moser, D. A., Braga, L., Raso, A., Zacchigna, S., Giacca, M., & Simon, P. (2014). Transgene Detection by Digital Droplet PCR. PLoS ONE, 9(11), e111781. DOI
  • Neuberger, E., & Simon, P. (2014). Auf der Suche nach geeigneten Nachweismethoden für Doping – das Transkriptom. Deutsche Zeitschrift für Sportmedizin, 2014, 272–278. DOI
  • Tug, S., Helmig, S., Menke, J., Zahn, D., Kubiak, T., Schwarting, A., & Simon, P. (2014). Correlation between cell free DNA levels and medical evaluation of disease progression in systemic lupus erythematosus patients. Cellular Immunology, 292(1–2), 32–39. DOI
  • Wang G, Neuberger E, Perikles S, Durussel J, McClure JD, McBride MW, Pitsiladis YP.Circulating microRNAs as biomarkers for recombinant human erythropoietin (r-HuEPO) doping detection. Acta Physiologica, Mar 2014; Volume: 210, Pages: 138-140, Supplement: 695.



  • Best, R., Simon, P., Nies, A., & Striegel, H. (2013). Influence of various preseason training in elite youth soccer player. Central European Journal of Medicine, 8. DOI
  • Dietz, P., Ulrich, R., Dalaker, R., Striegel, H., Franke, A. G., Lieb, K., & Simon, P. (2013). Associations between Physical and Cognitive Doping – A Cross-Sectional Study in 2.997 Triathletes. PLOS ONE, 8(11), e78702. DOI
  • Dietz, P., Striegel, H., Franke, A. G., Lieb, K., Simon, P., & Ulrich, R. (2013). Randomized response estimates for the 12-month prevalence of cognitive-enhancing drug use in university students. Pharmacotherapy, 33(1), 44–50. DOI
  • Ehlert, T., Simon, P., & Moser, D. A. (2013). Epigenetics in Sports. Sports Medicine, 43(2), 93–110.
  • Franke, A. G., Bagusat, C., Dietz, P., Hoffmann, I., Simon, P., Ulrich, R., & Lieb, K. (2013). Use of illicit and prescription drugs for cognitive or mood enhancement among surgeons. BMC Medicine, 11, 102. DOI
  • Giel, K. E., Zipfel, S., Schweizer, R., Braun, R., Ranke, M. B., Binder, G., Ehehalt, S., & DISKUS Study Group. (2013). Eating disorder pathology in adolescents participating in a lifestyle intervention for obesity: Associations with weight change, general psychopathology and health-related quality of life. Obesity Facts, 6(4), 307–316. DOI
  • Goeppert, B., Schmidt, C. R., Geiselhart, L., Dutruel, C., Capper, D., Renner, M., Vogel, M. N., Zachskorn, C., Zinke, J., Campos, B., Schmezer, P., Popanda, O., Wick, W., Weller, M., Meyermann, R., Schittenhelm, J., Harter, P. N., Simon, P., Weichert, W., … Mittelbronn, M. (2013). Differential expression of the tumor suppressor A-kinase anchor protein 12 in human diffuse and pilocytic astrocytomas is regulated by promoter methylation. Journal of Neuropathology and Experimental Neurology, 72(10), 933–941. DOI
  • Hoffmann, S. W., Tug, S., & Simon, P. (2013). Obesity prevalence and unfavorable health risk behaviors among German kindergarten teachers: Cross-sectional results of the kindergarten teacher health study. BMC Public Health, 13, 927. DOI
  • Michal, M., Simon, P., Gori, T., König, J., Wild, P. S., Wiltink, J., Tug, S., Sterzing, B., Unterrainer, J., Münzel, T., & Beutel, M. E. (2013). Psychodynamic Motivation and Training program (PMT) for the secondary prevention in patients with stable coronary heart disease: Study protocol for a randomized controlled trial of feasibility and effects. Trials, 14(1), 314. DOI



  • Botzenhardt, S., Lauer, U., & Simon, P. (2012). Gendoping: Nachweis prinzipiell möglich. Deutsches Ärzteblatt. LINK
  • Breitbach, S. (2012). Talentauswahl im Sport mittels genetischer Selektion, molekularer Diagnostik oder Sichtung: Enhancement durch Selektion? DOI
  • Breitbach S, Beiter T, Hudemann J, Striegel H, Simon P. Circulating, cell-free DNA concentrations in human plasma of soccer players before and after a typical soccer training session. Acta Physiologica, 2012.
  • Breitbach, S., Tug, S., & Simon, P. (2012). Circulating cell-free DNA: An up-coming molecular marker in exercise physiology. Sports Medicine (Auckland, N.Z.), 42(7), 565–586. DOI
  • Dietz, P., Hoffmann, S., Lachtermann, E., & Simon, P. (2012). Influence of exclusive resistance training on body composition and cardiovascular risk factors in overweight or obese children: A systematic review. Obesity Facts, 5(4), 546–560. DOI
  • Ernst, S., & Simon, P. (2013). A quantitative approach for assessing significant improvements in elite sprint performance: Has IGF-1 entered the arena? Drug Testing and Analysis, 5(6), 384–389. DOI
  • Hoffmann, S. W., Ulrich, R., & Simon, P. (2012). Refined analysis of the critical age ranges of childhood overweight: Implications for primary prevention. Obesity (Silver Spring, Md.), 20(10), 2151–2154. DOI
  • Kuschel, A., Simon, P., & Tug, S. (2012). Functional regulation of HIF-1α under normoxia—Is there more than post-translational regulation? Journal of Cellular Physiology, 227(2), 514–524. DOI
  • Moser, D. A., Neuberger, E. W. I., & Simon, P. (2012). A quick one-tube nested PCR-protocol for EPO transgene detection. Drug Testing and Analysis, 4(11), 870–875. DOI
  • Neuberger, E. W. I., Jurkiewicz, M., Moser, D. A., & Simon, P. (2012). Detection of EPO gene doping in blood. Drug Testing and Analysis, 4(11), 859–869. DOI
  • Schum, J., Blumenstock, G., Weber, K., Schweizer, R., Pfaff, C., Schurr, N., Ranke, M. B., Binder, G., Ehehalt, S., & DISKUS-Study Group. (2012). Variants of the FTO gene in obese children and their impact on body composition and metabolism before and after lifestyle intervention. Experimental and Clinical Endocrinology & Diabetes: Official Journal, German Society of Endocrinology [and] German Diabetes Association, 120(3), 128–131. DOI
  • Springer, F., Ehehalt, S., Sommer, J., Ballweg, V., Machann, J., Binder, G., Claussen, C. D., & Schick, F. (2012). Predicting volumes of metabolically important whole-body adipose tissue compartments in overweight and obese adolescents by different MRI approaches and anthropometry. European Journal of Radiology, 81(7), 1488–1494. DOI
  • Ulrich, R., Schröter, H., Striegel, H., & Simon, P. (2012). Asking sensitive questions: A statistical power analysis of randomized response models. Psychological Methods, 17(4), 623–641. DOI



  • Breitbach S. Genetische und molekulare Tests am Athleten. Medical Sports Network 1/2011
  • Breitbach S, Bohringer A, Simon P, Tug S. The differential expression of several mRNA variants of HIF1a during endurance exercise and under normobar hypoxia. Acta Physiologica 2011; Volume 201, Supplement 682 The 90th Annual Meeting of The German Physiological Society 26/03/2011-29/03/2011 Regensburg, Germany
  • Beiter, T., Fragasso, A., Hudemann, J., Niess, A. M., & Simon, P. (2011). Short-term treadmill running as a model for studying cell-free DNA kinetics in vivo. Clinical Chemistry, 57(4), 633–636. DOI
  • Beiter, T., Zimmermann, M., Fragasso, A., Hudemann, J., Niess, A. M., Bitzer, M., Lauer, U. M., & Simon, P. (2011). Direct and long-term detection of gene doping in conventional blood samples. Gene Therapy, 18(3), 225–231. DOI
  • Ehehalt, S., Binder, G., Schurr, N., Pfaff, C., Ranke, M. B., Schweizer, R., & DISKUS-Study Group. (2011). The functional muscle-bone unit in obese children—Altered bone structure leads to normal strength strain index. Experimental and Clinical Endocrinology & Diabetes: Official Journal, German Society of Endocrinology [and] German Diabetes Association, 119(6), 321–326. DOI
  • Ehehalt, S., Schweizer, R., Blumenstock, G., Pfaff, C., Schurr, N., Weber, K., Ranke, M. B., Binder, G., & DISKUS-Study Group. (2011). Investigation of myostatin serum levels before and after a 6-month lifestyle intervention program in obese children. Experimental and Clinical Endocrinology & Diabetes: Official Journal, German Society of Endocrinology [and] German Diabetes Association, 119(4), 238–242. DOI
  • Ehlert, T. (2011). Genetik und Epigenetik der körperlichen Leistungsfähigkeit. Deutsche Zeitschrift für Sportmedizin, 62(4), S. 86-91. LINK
  • Neuberger, E. W. I., Moser, D. A., & Simon, P. (2011). Principle considerations for the use of transcriptomics in doping research. Drug Testing and Analysis, 3(10), 668–675. DOI
  • Nolte, A., Secker, S., Walker, T., Greiner, T. O., Neumann, B., Simon, P., Ziemer, G., & Wendel, H. P. (2011). Veins are no arteries: Even moderate arterial pressure induces significant adhesion molecule expression of vein grafts in an ex vivo circulation model. The Journal of Cardiovascular Surgery, 52(2), 251–259. DOI
  • Schittenhelm, J., Simon, P., Harter, P. N., Zachskorn, C., Schlaszus, H., Röttger, F., Winkels, M., Weller, M., Meyermann, R., & Mittelbronn, M. (2011). CD133 expression is associated with small round blue cell tumour morphology in human central nervous system neoplasms. Histopathology, 58(5), 739–749. DOI
  • Springer, F., Ehehalt, S., Sommer, J., Ballweg, V., Machann, J., Binder, G., Claussen, C. D., Schick, F., & for the DISKUS-Study Group. (2011). Assessment of relevant hepatic steatosis in obese adolescents by rapid fat-selective GRE imaging with spatial-spectral excitation: A quantitative comparison with spectroscopic findings. European Radiology, 21(4), 816–822. DOI
  • Walsh, N. P., Gleeson, M., Shephard, R. J., Gleeson, M., Woods, J. A., Bishop, N. C., Fleshner, M., Green, C., Pedersen, B. K., Hoffman-Goetz, L., Rogers, C. J., Northoff, H., Abbasi, A., & Simon, P. (2011). Position statement. Part one: Immune function and exercise. Exercise Immunology Review, 17, 6–63. LINK




  • Ciobanu, D. C., Lu, L., Mozhui, K., Wang, X., Jagalur, M., Morris, J. A., Taylor, W. L., Dietz, K., Simon, P., & Williams, R. W. (2010). Detection, Validation, and Downstream Analysis of Allelic Variation in Gene Expression. Genetics, 184(1), 119–128. DOI
  • Ehlert, T., Simon, P., & Tug, S. (2010). Misleading Interpretations and Public Misinformation on Human Growth Hormone in Athletes. Annals of Internal Medicine, 153(5), 345–346. DOI
  • Lehmann, R., Zhao, X., Weigert, C., Simon, P., Fehrenbach, E., Fritsche, J., Machann, J., Schick, F., Wang, J., Hoene, M., Schleicher, E. D., Häring, H.-U., Xu, G., & Niess, A. M. (2010). Medium chain acylcarnitines dominate the metabolite pattern in humans under moderate intensity exercise and support lipid oxidation. PloS One, 5(7), e11519. DOI
  • Striegel, H., Ulrich, R., & Simon, P. (2010). Randomized response estimates for doping and illicit drug use in elite athletes. Drug and Alcohol Dependence, 106(2–3), 230–232. DOI
  • Waalkes, S., Simon, P., Hennenlotter, J., Knapp, J., Tezval, H., Serth, J., Stenzl, A., Kuczyk, M. A., & Merseburger, A. S. (2010). Altered expression of Akt signaling pathway parameters in prostate needle biopsies derived from benign, adjacent and cancerous tissue. Oncology Reports, 23(5), 1257–1260. DOI



  • Avci-Adali, M., Nolte, A., Simon, P., Ziemer, G., & Wendel, H. P. (2009). Porcine EPCs downregulate stem cell markers and upregulate endothelial maturation markers during in vitro cultivation. Journal of Tissue Engineering and Regenerative Medicine, 3(7), 512–520. DOI
  • Beiter, T., Reich, E., Williams, R. W., & Simon, P. (2009). Antisense transcription: A critical look in both directions. Cellular and Molecular Life Sciences: CMLS, 66(1), 94–112. DOI
  • Hansel, J., & Simon, P. (2009). Letter by Hansel and Simon regarding article, „Body mass index and vigorous physical activity and the risk of heart failure among men“. Circulation, 120(11), e90; author reply e91. DOI
  • Hansel, J., Solleder, I., Gfroerer, W., Muth, C. M., Paulat, K., Simon, P., Heitkamp, H.-C., Niess, A., & Tetzlaff, K. (2009). Hypoxia and cardiac arrhythmias in breath-hold divers during voluntary immersed breath-holds. European Journal of Applied Physiology, 105(5), 673–678. DOI
  • Nolte, A., Raabe, C., Walker, T., Simon, P., Ziemer, G., & Wendel, H. P. (2009). Optimized basic conditions are essential for successful siRNA transfection into primary endothelial cells. Oligonucleotides, 19(2), 141–150. DOI
  • Mittelbronn, M., Harter, P., Warth, A., Lupescu, A., Schilbach, K., Vollmann, H., Capper, D., Goeppert, B., Frei, K., Bertalanffy, H., Weller, M., Meyermann, R., Lang, F., & Simon, P. (2009). EGR-1 is regulated by N-methyl-D-aspartate-receptor stimulation and associated with patient survival in human high grade astrocytomas. Brain Pathology (Zurich, Switzerland), 19(2), 195–204. DOI
  • Schaible, E., Boehringer, A., Callau, D., Niess, A. M., & Simon, P. (2009). Exercise and menstrual cycle dependent expression of a truncated alternative splice variant of Hif1alpha in leukocytes. Exercise Immunology Review, 15, 145–156. LINK
  • Schittenhelm, J., Beschorner, R., Simon, P., Tabatabai, G., Herrmann, C., Schlaszus, H., Capper, D., Weller, M., Meyermann, R., & Mittelbronn, M. (2009). Diagnostic value of WT1 in neuroepithelial tumours. Neuropathology and Applied Neurobiology, 35(1), 69–81. DOI




  • Beiter, T., Zimmermann, M., Fragasso, A., Armeanu, S., Lauer, U. M., Bitzer, M., Su, H., Young, W. L., Niess, A. M., & Simon, P. (2008). Establishing a novel single-copy primer-internal intron-spanning PCR (spiPCR) procedure for the direct detection of gene doping. Exercise Immunology Review, 14, 73–85. LINK Beschreibung des Verfahrens:
  • Hennenlotter, J., Ohneseit, P. A., Simon, P., Merseburger, A. S., Serth, J., Kuehs, U., Kramer, M., Hartmann, J. T., Stenzl, A., & Kuczyk, M. A. (2008). PTEN and p27Kip1 are not downregulated in the majority of renal cell carcinomas—Implications for Akt activation. Oncology Reports, 19(5), 1141–1147. LINK
  • Merseburger, A. S., Hennenlotter, J., Kuehs, U., Simon, P., Kruck, S., Koch, E., Stenzl, A., & Kuczyk, M. A. (2008). Activation of PI3K is associated with reduced survival in renal cell carcinoma. Urologia Internationalis, 80(4), 372–377. DOI
  • Merseburger, A. S., Kramer, M. W., Hennenlotter, J., Simon, P., Knapp, J., Hartmann, J. T., Stenzl, A., Serth, J., & Kuczyk, M. A. (2008). Involvement of decreased Galectin-3 expression in the pathogenesis and progression of prostate cancer. The Prostate, 68(1), 72–77. DOI
  • Northoff, H., Symons, S., Zieker, D., Schaible, E. V., Schäfer, K., Thoma, S., Löffler, M., Abbasi, A., Simon, P., Niess, A. M., & Fehrenbach, E. (2008). Gender- and menstrual phase dependent regulation of inflammatory gene expression in response to aerobic exercise. Exercise Immunology Review, 14, 86–103. LINK
  • Schwab, M., Lupescu, A., Mota, M., Mota, E., Frey, A., Simon, P., Mertens, P. R., Floege, J., Luft, F., Asante-Poku, S., Schaeffeler, E., & Lang, F. (2008). Association of SGK1 gene polymorphisms with type 2 diabetes. Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology, 21(1–3), 151–160. DOI




  • Beschorner, R., Dietz, K., Schauer, N., Mittelbronn, M., Schluesener, H. J., Trautmann, K., Meyermann, R., & Simon, P. (2007). Expression of EAAT1 reflects a possible neuroprotective function of reactive astrocytes and activated microglia following human traumatic brain injury. Histology and Histopathology, 22(5), 515–526. DOI
  • Beschorner, R., Simon, P., Schauer, N., Mittelbronn, M., Schluesener, H. J., Trautmann, K., Dietz, K., & Meyermann, R. (2007). Reactive astrocytes and activated microglial cells express EAAT1, but not EAAT2, reflecting a neuroprotective potential following ischaemia. Histopathology, 50(7), 897–910. DOI
  • Beiter, T., Reich, E., Weigert, C., Niess, A. M., & Simon, P. (2007). Sense or antisense? False priming reverse transcription controls are required for determining sequence orientation by reverse transcription-PCR. Analytical Biochemistry, 369(2), 258–261. DOI
  • Mehling, M., Simon, P., Mittelbronn, M., Meyermann, R., Ferrone, S., Weller, M., & Wiendl, H. (2007). WHO grade associated downregulation of MHC class I antigen-processing machinery components in human astrocytomas: Does it reflect a potential immune escape mechanism? Acta Neuropathologica, 114(2), 111–119.  DOI
  • Mittelbronn, M., Capper, D., Bunz, B., Dietz, K., Goeppert, B., Ajaaj, R., Tabatabai, G., Stubenvoll, F., Schlaszus, H., Merseburger, A. S., Becker, R., Freudenstein, D., Wick, W., Weller, M., Meyermann, R., & Simon, P. (2007). De novo erythropoietin receptor (EPO-R) expression in human neoplastic glial cells decreases with grade of malignancy but is favourably associated with patient survival. Neuropathology and Applied Neurobiology, 33(3), 299–307. DOI
  • Mittelbronn, M., Simon, P., Löffler, C., Capper, D., Bunz, B., Harter, P., Schlaszus, H., Schleich, A., Tabatabai, G., Goeppert, B., Meyermann, R., Weller, M., & Wischhusen, J. (2007). Elevated HLA-E levels in human glioblastomas but not in grade I to III astrocytomas correlate with infiltrating CD8+ cells. Journal of Neuroimmunology, 189(1–2), 50–58. DOI
  • Niess, A. M., & Simon, P. (2007). Response and adaptation of skeletal muscle to exercise—The role of reactive oxygen species. Frontiers in Bioscience: A Journal and Virtual Library, 12, 4826–4838. DOI
  • Simon, P., Schneck, M., Hochstetter, T., Koutsouki, E., Mittelbronn, M., Merseburger, A., Weigert, C., Niess, A., & Lang, F. (2007). Differential regulation of serum- and glucocorticoid-inducible kinase 1 (SGK1) splice variants based on alternative initiation of transcription. Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology, 20(6), 715–728. DOI
  • Walker, T., Wendel, H. P., Tetzloff, L., Raabe, C., Heidenreich, O., Simon, P., Scheule, A. M., & Ziemer, G. (2007). Inhibition of adhesion molecule expression on human venous endothelial cells by non-viral siRNA transfection. Journal of Cellular and Molecular Medicine, 11(1), 139–147. DOI
  • Warth, A., Simon, P., Capper, D., Goeppert, B., Tabatabai, G., Herzog, H., Dietz, K., Stubenvoll, F., Ajaaj, R., Becker, R., Weller, M., Meyermann, R., Wolburg, H., & Mittelbronn, M. (2007). Expression pattern of the water channel aquaporin-4 in human gliomas is associated with blood-brain barrier disturbance but not with patient survival. Journal of Neuroscience Research, 85(6), 1336–1346. DOI
  • Weigert, C., Düfer, M., Simon, P., Debre, E., Runge, H., Brodbeck, K., Häring, H. U., & Schleicher, E. D. (2007). Upregulation of IL-6 mRNA by IL-6 in skeletal muscle cells: Role of IL-6 mRNA stabilization and Ca2+-dependent mechanisms. American Journal of Physiology. Cell Physiology, 293(3), C1139-1147. DOI
  • Weyrich, P., Machicao, F., Staiger, H., Simon, P., Thamer, C., Machann, J., Schick, F., Guirguis, A., Fritsche, A., Stefan, N., & Häring, H.-U. (2007). Role of AMP-activated protein kinase gamma 3 genetic variability in glucose and lipid metabolism in non-diabetic whites. Diabetologia, 50(10), 2097–2106. DOI



  • Merseburger, A. S., Hennenlotter, J., Simon, P., Müller, C. C., Kühs, U., Knüchel-Clarke, R., Moul, J. W., Stenzl, A., & Kuczyk, M. A. (2006). Activation of the PKB/Akt pathway in histological benign prostatic tissue adjacent to the primary malignant lesions. Oncology Reports, 16(1), 79–83. LINK
  • Simon, P., Fehrenbach, E., & Niess, A. M. (2006). Regulation of immediate early gene expression by exercise: Short cuts for the adaptation of immune function. Exercise Immunology Review, 12, 112–131. LINK
  • Simon, P., Striegel, H., Aust, F., Dietz, K., & Ulrich, R. (2006). Doping in fitness sports: Estimated number of unreported cases and individual probability of doping. Addiction (Abingdon, England), 101(11), 1640–1644. DOI
  • Striegel, H., Simon, P., Frisch, S., Roecker, K., Dietz, K., Dickhuth, H.-H., & Ulrich, R. (2006). Anabolic ergogenic substance users in fitness-sports: A distinct group supported by the health care system. Drug and Alcohol Dependence, 81(1), 11–19. DOI
  • Striegel, H., Simon, P., Wurster, C., Niess, A. M., & Ulrich, R. (2006). The use of nutritional supplements among master athletes. International Journal of Sports Medicine, 27(3), 236–241. DOI



  • Merseburger, A. S., Hennenlotter, J., Simon, P., Kruck, S., Koch, E., Horstmann, M., Kuehs, U., Küfer, R., Stenzl, A., & Kuczyk, M. A. (2005). Membranous expression and prognostic implications of epidermal growth factor receptor protein in human renal cell cancer. Anticancer Research, 25(3B), 1901–1907. LINK
  • Merseburger, A. S., Hennenlotter, J., Simon, P., Ohneseit, P. A., Kuehs, U., Kruck, S., Koch, E., Vogel, U., Stenzl, A., & Kuczyk, M. A. (2005). Cathepsin D expression in renal cell cancer-clinical implications. European Urology, 48(3), 519–526. DOI
  • Neumann, M., Mittelbronn, M., Simon, P., Vanmassenhove, B., de Silva, R., Lees, A., Klapp, J., Meyermann, R., & Kretzschmar, H. A. (2005). A new family with frontotemporal dementia with intronic 10+3 splice site mutation in the tau gene: Neuropathology and molecular effects. Neuropathology and Applied Neurobiology, 31(4), 362–373. DOI
  • Richartz, E., Batra, A., Simon, P., Wormstall, H., Bartels, M., Buchkremer, G., & Schott, K. (2005). Diminished production of proinflammatory cytokines in patients with Alzheimer’s disease. Dementia and Geriatric Cognitive Disorders, 19(4), 184–188. DOI
  • Richartz, E., Stransky, E., Batra, A., Simon, P., Lewczuk, P., Buchkremer, G., Bartels, M., & Schott, K. (2005). Decline of immune responsiveness: A pathogenetic factor in Alzheimer’s disease? Journal of Psychiatric Research, 39(5), 535–543. DOI
  • Striegel, H., Rössner, D., Simon, P., & Niess, A. M. (2005). The World Anti-Doping Code 2003—Consequences for physicians associated with elite athletes. International Journal of Sports Medicine, 26(3), 238–243. DOI
  • Zieker, D., Fehrenbach, E., Dietzsch, J., Fliegner, J., Waidmann, M., Nieselt, K., Gebicke-Haerter, P., Spanagel, R., Simon, P., Niess, A. M., & Northoff, H. (2005). CDNA microarray analysis reveals novel candidate genes expressed in human peripheral blood following exhaustive exercise. Physiological Genomics, 23(3), 287–294. DOI



  • Buck, C., Schaeffel, F., Simon, P., & Feldkaemper, M. (2004). Effects of positive and negative lens treatment on retinal and choroidal glucagon and glucagon receptor mRNA levels in the chicken. Investigative Ophthalmology & Visual Science, 45(2), 402–409. DOI
  • Simon, P., Schott, K., Williams, R. W., & Schaeffel, F. (2004). Posttranscriptional regulation of the immediate-early gene EGR1 by light in the mouse retina. The European Journal of Neuroscience, 20(12), 3371–3377. DOI
  • Simon, P., Feldkaemper, M., Bitzer, M., Ohngemach, S., & Schaeffel, F. (2004). Early transcriptional changes of retinal and choroidal TGFbeta-2, RALDH-2, and ZENK following imposed positive and negative defocus in chickens. Molecular Vision, 10, 588–597. LINK




  • Schaeffel, F., Simon, P., Feldkaemper, M., Ohngemach, S., & Williams, R. W. (2003). Molecular biology of myopia. Clinical & Experimental Optometry, 86(5), 295–307. DOI
  • Simon, P. (2003). Q-Gene: Processing quantitative real-time RT-PCR data. Bioinformatics (Oxford, England), 19(11), 1439–1440. DOI
  • Zimmermann, A. K., Simon, P., Seeburger, J., Hoffmann, J., Ziemer, G., Aebert, H., & Wendel, H. P. (2003). Cytokine gene expression in monocytes of patients undergoing cardiopulmonary bypass surgery evaluated by real-time PCR. Journal of Cellular and Molecular Medicine, 7(2), 146–156. DOI



  • Dettweiler, U., & Simon, P. (2001). Points to consider for ethics committees in human gene therapy trials. Bioethics, 15(5–6), 491–500. DOI

Veröffentlichte Patentanmeldung:

(WO/2007/124861) Detection of Transgenic DNA (tDNA), PCT/EP2007/003385